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Oak wood contains a specific profile of bioactive polyphenols named roburins that are part of the ellagitannins (ETs). Robuvit® is standardized and specified to contain at least 40% polyphenols including grandinin, ellagic acid (EA) and gallic acid extracted from the wood of oak. Ellagitannins in oak are metabolized by the microflora of the gut to urolithins. Urolithins have also been shown to support mitophagy and generation of new mitochondria for energy production.
Preliminary human data with oak extract showed reduced oxidative stress markers, including advanced oxidation protein products and lipoperoxides in serum, as well as support for total antioxidant capacity and activities of antioxidant enzymes, Cu/Zn superoxide dismutase and catalase in red blood cells. In a study in healthy elderly individuals, the analysis focused on the comparison of pre and post effects of Robuvit® on symptoms of fatigue. In the total group of volunteers, a significant increase of average question scores was found in three of four subscales of feelings (energy, tiredness, and tension) after 4 weeks of Robuvit® administration. These results demonstrate a positive effect of Robuvit® on mental and energy levels in healthy individuals without any unwanted side effects. In another pilot study, Robuvit® showed benefits in overall mood at a dose of 200 mg daily.‡ Coenzyme Q10 is an important cofactor in the mitochondrial electron transport chain, the biochemical pathway in cellular respiration from which adenosine triphosphate (ATP) and metabolic energy is derived. Since nearly all cellular activities are dependent upon energy, coenzyme Q10 is essential for the health of all human tissues and organs. The biosynthesis of CoQ10 decreases with age, making supplementation an alternative option for ensuring adequate energy production.
Curcumin has shown promise in preclinical models of occasional fatigue, potentially by supporting mitochondrial function and immune mediator balance. Curcumin has demonstrated in human trials to moderate cyclooxygenase-2 (COX-2), prostaglandins, leukotrienes, and other cytokines involved in immune signaling pathways. BioPerine® is the only product sourced out of piperine to obtain a patented status for its ability to increase the bioavailability of nutritional compounds. It has undergone clinical studies to substantiate safety and efficacy for nutritional use. Bioavailability of curcumin (2,000 mg) when co-administered with BioPerine® (20 mg) was enhanced by 20-fold or 2,000% compared to bioavailability of curcumin alone.